IMPDH1 and B-cell chronic lymphocytic leukemia: In hematological cancers like mantle cell lymphoma (MCL), diffuse large B-cell lymphoma (DLBCL), chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), and anaplastic large cell lymphoma (ALCL), IMPDH2 levels are significantly higher than IMPDH1 (Figure S2c, in the Supplementary Materials).