In hematological cancers like mantle cell lymphoma (MCL), diffuse large B-cell lymphoma (DLBCL), chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), and anaplastic large cell lymphoma (ALCL), IMPDH2 levels are significantly higher than IMPDH1 (Figure S2c, in the Supplementary Materials). The gene discussed is IMPDH2; the disease is B-cell chronic lymphocytic leukemia.