For example, in HN12-derived EVs (HPV+), RNA-seq analysis showed an oncogenic transcriptome that favored genes regulating cell cycle progression, migration, and tumor development, including SGK1, MAD1L1, and EEF2, all of which correlate with poor patient survival in head and neck squamous cell carcinoma (HNSCC) cohorts. The gene discussed is MAD1L1; the disease is head and neck squamous cell carcinoma.