Notably, exosomes from HPV-16 E7-expressing non-small cell lung cancer (NSCLC) cells dramatically promoted EMT, evidenced by the upregulation of mesenchymal markers (Vimentin, N-cadherin, Snail1, Slug, Twist1) and suppression of E-cadherin. This evidence concerns the gene CDH2 and non-small cell lung carcinoma.