Selective cargo packaging into HPV+ exosomes, including viral oncogenes (E6/E7), oncogenic mRNAs (EGFR, TP53), and regulatory non-coding RNAs such as HOTAIR and MALAT1, indicates that exosome content is not random but purposefully directed to favor tumor growth and immune evasion [34,42,49,50,51,52,53,54,55,56,57]. The gene discussed is MALAT1; the disease is neoplasm.