Other genes which showed a significant co-occurrence with CSF3R mutations in AML are signaling proteins, such as, KIT, FLT3 and also NRAS with both activating and hyperactive CSF3R mutations [78,80,119], as well as NPM1 [78], especially in concert with CEBPA [80], and the transcription factor IKZF1 [120]. This evidence concerns the gene CSF3R and acute myeloid leukemia.