AKT1 and malignant endocrine neoplasm: Mechanisms similar to the role of lncRNA H19 in regulating PI3K/AKT signaling in thyroid cancer have been defined in other endocrine tumors like pancreatic neuroendocrine neoplasms, but in the case of thyroid cancer, it is further evidence that H19 is a central player in tumor progression through the regulation of the PI3K/AKT pathway [42].