For instance, LINC00671 is a potential tumor suppressor, as it downregulates lactate dehydrogenase A (LDHA), a major glycolytic enzyme, restraining glycolysis, tumor growth, and metastasis, before its expression is inhibited under hypoxic conditions through the activation of STAT3, which enhances LDHA expression and enhances cancer progression [84]. This evidence concerns the gene HK1 and neoplasm.