In agreement with this finding, research across cancer types supports lncRNA→miRNA→sirtuin pathways that connect non-coding RNA signaling with metabolic regulation: in particular, a validated MEG3–miR-181a–SIRT1 axis is associated with markers of metabolic reprogramming in human cohorts and illustrates how lncRNAs can influence sirtuin activity indirectly [80]. This evidence concerns the gene SIRT1 and cancer.