TUG1 and neoplasm: For example, TUG1 sponges miR-141 and miR-340, resulting in increased PD-L1 and CD47 on tumors, as well as TUG1 binding the transcription factor YBX1, further enhancing the transcription of these immune-evasive signals, thus establishing a self-perpetuating feedback loop that promotes tumor escape [15].