NBR2 and neoplasm: On the contrary, several lncRNAs serve to promote anti-tumor immunity; NBR2, which is typically downregulated in tumors, serves to sponge miR-19a and release immunosuppressive targets from inhibition; this has the net effect of repolarizing macrophages to an M1 phenotype, and reducing oncogenic HIF-1α and AKT/mTOR signaling to suggest that the restoration of specific lncrRNA–miRNA axes has the potential to bolster host immunity [148].