Some lncRNAs, including H19 and ABHD11-AS1, are upregulated in thyroid tumors, which enhance EMT, proliferation, invasion, and angiogenesis, most often by acting as sponge molecules for microRNAs, or modulating key pathways, such as PI3K/Akt and ERK/MAPK [61]. The gene discussed is AKT1; the disease is thyroid tumor.