SPTY2D1 and thyroid cancer: For instance, silencing oncogenic lncRNAs such as GLTC or FAM230B may inhibit tumor progression and diminish radioiodine resistance, and, in contrast, restoring tumor-suppressive lncRNAs such as SLC26A4-AS1, SPTY2D1-AS1, LINC00969, or GAS8-AS1 could also inhibit metastasis and enhance chemosensitivity or autophagy in thyroid cancer cells [29,85,130,131,132,133].