In the case of papillary thyroid carcinoma, lncRNAs are involved in the regulation of multiple important signaling pathways, such as PI3K/Akt and Wnt and the facilitation of the epithelial–mesenchymal transition, and they act as molecular sponges for microRNAs: all of which promote tumor progression and immune evasion [51]. The gene discussed is PIK3CG; the disease is thyroid gland papillary carcinoma.