In thyroid cancers, particularly the papillary and anaplastic forms, lncRNAs can modulate the expression and activity of TERT, the catalytic subunit of telomerase, through various mechanisms such as epigenetic regulation, sponging of microRNAs, and cooperating with signaling pathways such as PI3K/Akt and Wnt [51]. The gene discussed is PIK3CG; the disease is thyroid gland carcinoma.