Using an rRNA-depleted bulk RNA-seq cohort with matched normal tissue and complementary single-cell analyses, observation of the expression of MEG3 was highly associated with lymph node metastasis, and with increased tumor-associated fibrosis characterized by greater infiltration of cancer-associated fibroblasts (CAFs) in human samples. Here, MEG3 is linked to metastatic malignant neoplasm in the lymph nodes.