Glypican-3 (GPC3) is a cell surface heparan sulfate proteoglycan that is highly overexpressed in a large subset (~77%) [5] of HCC but largely absent in normal liver tissue and most benign hepatic lesions [6,7]; this expression profile makes it an attractive tumor-specific biomarker for targeted theranostic applications. This evidence concerns the gene GPC3 and neoplasm.