In the GPC3-negative SNU449 model, no notable difference in tumor signal enhancement was observed between DOTA-Gd and 1G12-DOTA-Gd (Figure 2b); the CNR over time was also comparable between DOTA-Gd and 1G12-DOTA-Gd (Figure 2c). The gene discussed is GPC3; the disease is neoplasm.