Moreover, Rad51 and γ-H2AX foci were mislocalized in FGFR-inhibited GIST, and the amount of Rad51 was substantially decreased in H2AX-immunoprecipitated complexes, thereby illustrating the defect of Rad51 recombinase loading to the doxorubicin-induced DSBs [159]. Here, H2AX is linked to gastrointestinal stromal tumor.