Epigenetic reprogramming of immune cells can be triggered by factors secreted by cancer cells such as the cytokines, Interleukin-10 (IL-10) and Transforming Growth Factor Beta (TGF-β), as well as by physical properties of the TME, such as hypoxia, and the extracellular matrix (ECM) [10,11,12]. This evidence concerns the gene IL10 and cancer.