Specifically, Deforzh et al. (2024) showed that HOXDeRNA (LINC01116) binds across the genome to the promoters of at least 35 glioma-specific transcription factors, including core stem cell regulators like SOX2, OLIG2, POU3F2, and ASCL1 [17]. The gene discussed is ASCL1; the disease is central nervous system cancer.