Top DEGs, including PGK1, DLAT, SHMT2, TSR1, C1QBP, BOP1, KCNMA1, CACNA1D, CACNA2D1, NUMB, WASF2 and BVES, were involved in these processes, as shown in Figure 2A. PGK1, a gene involved in metabolism-related processes, was the most significantly differentially expressed gene in meningiomas stratified according to the WHO tumor grade, as depicted in Figure 1C. Expression of phosphoglycerate kinase 1 (encoded by PGK1) was examined in set of a twenty-four meningioma samples, comprising six meningothelial, six fibrous, six atypical and six anaplastic meningiomas. The gene discussed is SHMT2; the disease is neoplasm.