Since we found that loss of P53 increased the stem cell population that expressed SCA-1 and enhanced colony formation in vitro, and was associated with high expression of another stem cell marker (CD44) in vivo, stem cells expressing these two markers with loss of P53 may act as tumor-initiating cells, which could develop into the precursor lesions of STIC found in the fallopian tube fimbria. The gene discussed is TP53; the disease is neoplasm.