TP53 and cancer: Since STICs are thought to arise from fallopian tube cell outgrowths that frequently have TP53 mutation and these lesions have been detected in BRCA-1 carriers [23,28,29], this study aimed to define the role of TP53 and BRCA-1 mutations in fallopian tube cells by characterizing the potential involvement in the regulation of stem-like cell proliferation and gene expressions that may be relevant to cancer-initiating cells.