DUOX2 and familial pancreatic carcinoma: Transwell migration/invasion and wound-healing assays further revealed that DUOX2 knockdown attenuated tumor cell migratory and invasive capacities, whereas DUOX2 overexpression robustly promoted these behaviors (Figure 4L,M; Supplementary Figure S5A–F), confirming the critical role of DUOX2 in pancreatic cancer metastasis.