DCC and neoplasm: Additionally, several mutations not previously reported in OSCC sequencing studies were detected in 7% of cases including mutations in ARID1A (chromatin remodeling), BIRC6 (apoptosis inhibition), DCC (neural regulation and tumor suppression), and NCOR1 (transcriptional inhibition) [13,14,15,16,19,20,21,22,23,24,25].