PPARGC1A and adiponectin deficiency: ↓ The development of hyperglycemia, insulin resistance, dyslipidemia, hyperleptinemia, and hypoadiponectinemia levels demonstrates metabolic syndrome.Improves ADBEXE combined with oral melatonin synergistically decreases serum corticosterone and hippocampus tissue level of inflammatory cytokines, and improves ATP levelUpregulate the expression of BDNF, peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), and mitochondrial biogenesis-related proteins, glucose transporter type 4 (GLUT4) in hippocampus tissue.