CuNP and exercise:↓ CKMB, cardiac troponin I (cTnI), LDHImprove nitrite/nitrate concentration and lipid profile↓ OSWortmannin reversed these changes and prevented the reduction of phosphorylated glycogen synthase kinase-3 beta. Low-dose CuNP and EXE: prevent myocardial infarction. The gene discussed is GSK3B; the disease is myocardial infarction.