Ameliorated hypertension, IR, and biochemical alteration induced by diabetes↑ EXE performance.The expression of GLUT4 mitochondrial biogenesis-associated proteins, such as peroxisome PGC-1α, nuclear respiratory factor, and mitochondrial transcription factor-A, increased in skeletal and cardiac muscle in the diabetes plus melatonin and exercise group. Here, TFAM is linked to Hypertension.