↓ Anxiety and depression-like behaviors (ADB)↑ Newborn cells (mostly differentiated into neurons, bromodeoxyuridine [BrdU+]DCX+ cells or BrdU+NeuN+ cells, and a few astrocytes, BrdU+ glial fibrillary acidic protein (GFAP+) cells)↑ NeuN, postsynaptic density 95, synaptophysin, B-cell lymphoma-2 (Bcl-2)↓ GFAP protein. Here, SYP is linked to Anxiety.