Swimming caused:↓ Pain and joint stiffnessDevelopment of histological and radiological osteoarthritis occurrence in the knee joints↓ Serum C-reactive protein (CRP) and tissue cartilage oligomeric matrix protein levelsRestoring the miR-130a and histone deacetylase 3The dual therapy caused:Increased peroxisome proliferator-activated receptor gamma (PPAR-γ) alongside ↓ nuclear factor kappa light-chain-enhancer of activated B lymphocytes (NF-κB) and its inflammatory cytokine targets TNF-α and IL-1β.↓ Matrix metalloproteinase-1 and MMP-13. Here, CRP is linked to osteoarthritis.