GPX4 and depressive disorder: Studies have shown that System Xc-/GPX4 is involved in the progression of chronic social defeat stress (CSDS)-induced depression, which can be ameliorated by edaravone (a free radical scavenger) through the Sirt1/Nrf2/HO-1/Gpx4 axis, thus mitigating neuronal loss and oxidative stress damage in the cortex and hippocampus of mice [20].