TP53 and central nervous system cancer: Aberrations in growth signaling, proliferation, and angiogenesis (MAPK, EGFR, and VEGF pathways) and pro-oncogenes such as TP53, MYB/MTBL1, BRAF, FGFR, histone H3, and FGFR are commonly seen in pediatric gliomas [74,75,76].