RNF213 and ischemic stroke: Investigations of the RNF213 Arg4810Lys mutation have revealed that it disrupts angiogenic signaling, endothelial function, vascular remodeling, and immune regulation, effects worsened by stressors such as hypoxia and inflammation, and is implicated in MMD, intracranial stenosis, ischemic stroke, and atherosclerosis [7].