KCNA3 and Hyperglycemia: We have also shown that hyperglycemia decreases astrocytic function, such as glutamate uptake and potassium buffering, due to a reduction in the function and expression of the Kir4.1 potassium channel; taking these findings together with the findings of Hansen’s group, we are able to correlate the reduction in the glutamate clearance of astrocytes with the reduction in the Kir4.1 expression due to hyperglycemic conditions and MG levels [12,20,39,40].