In summary, these mutations reshape spinal cord tumor biology by disrupting the hallmarks of cancer: (1) proliferation and cell cycle deregulation (MYCN, TP53), (2) epigenetic reprogramming and stemness (H3 K27M, HOXB13), (3) constitutive growth signaling (BRAF V600E), (4) replicative immortality (TERT promoter). The gene discussed is HOXB13; the disease is neoplasm.