In summary, these mutations reshape spinal cord tumor biology by disrupting the hallmarks of cancer: (1) proliferation and cell cycle deregulation (MYCN, TP53), (2) epigenetic reprogramming and stemness (H3 K27M, HOXB13), (3) constitutive growth signaling (BRAF V600E), (4) replicative immortality (TERT promoter). This evidence concerns the gene MYCN and neoplasm.