In this study, it was further found that there were no statistical differences between the cognitive dysfunction group and the group without cognitive impairment in total cholesterol, triglycerides, LDL, HDL, lactate, and leukocyte counts; however, serum C-reactive protein (CRP) levels in the cognitive dysfunction group were significantly higher than those in the control group (p = 0.089), suggesting that CRP may serve as a NIID-related cognitive impairment early biomarkers, a result that suggests that inflammatory responses may be involved in the pathogenesis of NIID. The gene discussed is CRP; the disease is neuronal intranuclear inclusion disease.