In this study, although some ubiquitination-related processes were identified in NCCs during bacterial infection, as well as the studies in zebrafish and rainbow trout indicated the function of ubiquitination against bacterial infection, such as the regulation on NF-κB pathway [39] and the inhibition of inflammation [40], more extensive and robust ubiquitination-mediated degradation events were observed during the antiviral responses of NCCs [17,19,20]. Here, NFKB1 is linked to bacterial infectious disease.