ADGRF3, ADGRF4, ADGRD1, ADGRE2, ADGRG3, ADGRL1, ADGRG7, ADGRD2, ADGRG2, ADGRE1, ADGRE5, ADGRG4, ADGRL4, ADGRE3, and ADGRL3 have not yet been associated with cardiac development or congenital heart defects; ADGRF4 associated with enamel mineralization [387]; ADGRL1 implicated in neurodevelopmental disorders [388]; ADGRG7 implicated in familial endometriosis [389]; ADGRG2 implicated in congenital bilateral absence of the vas deferens [390]; ADGRL4 involved in vascular remodeling during development [385]; ADGRL3 involved in neurogenesis [391]. Here, ADGRE5 is linked to neurodevelopmental disorder.