Many of the above genes have been associated with heart defects in vertebrate models as well, including Lysine methyltransferase 2C (KMT2C) and Lysine methyltransferase 2D (KMT2D) (encoding for core subunits of the COMPASS complex series in vertebrates as well) [328], and are associated with defects such as ventricular septal defects, Tetralogy of Fallot [332], and Kabuki syndrome [333]. The gene discussed is KMT2C; the disease is ventricular septal defect 1.