HOXB7, HOXD8 cardiac expression altered in embryos after maternal alcohol consumption, via RNA-sequencing data [470]; HOXB7 gain-of-function mutation associated with VSD, along with other congenital defects (cleft palate, renal anomalies, skeletal abnormalities [craniocervical, costosternal regions]) [471] (mouse). This evidence concerns the gene HOXD8 and ventricular septal defect.