SHH and situs inversus: SHH protein mutations/SHH-related signaling pathway mutations associated with heart defects related to the establishment of left–right asymmetry due to dysfunction of midline structures [286], including situs inversus, dextrocardia, defects in pharyngeal arch patterning, atrioventricular septal defects, transposition of the great arteries, and DORV [287] (mouse)