Many of the above genes have been associated with heart defects in vertebrate models as well, including Lysine methyltransferase 2C (KMT2C) and Lysine methyltransferase 2D (KMT2D) (encoding for core subunits of the COMPASS complex series in vertebrates as well) [328], and are associated with defects such as ventricular septal defects, Tetralogy of Fallot [332], and Kabuki syndrome [333]. This evidence concerns the gene KMT2D and Kabuki syndrome.