Cardiac-specific miRNAs, such as hsa-miR-499a-5p and hsa-miR-1-3p, are suitable as acute diagnostic markers of myocardial infarction, as well as for identifying patients at increased risk of death during the first year after acute myocardial infarction, especially when combined with NT-proBNP levels [38]. The gene discussed is NPPB; the disease is acute myocardial infarction.