Wild-type TRβ and mutant TRβ exert opposing regulatory effects on this pathway: wild-type TRβ promotes the dephosphorylation of Akt via protein phosphatase 2A (PP2A), thereby inhibiting Akt activity, suppressing cancer cell proliferation and migration, and exerting anti-tumor effects [101]. The gene discussed is AKT1; the disease is neoplasm.