MPN thrombosis is also related to epigenetic dysregulations, that refers to the mutations in genes that encode proteins which regulate the chromatin structure (ASXL1, TET2, IDH1/2, EZH2, IKZF1, JAK2 V617F, and PRMT5), and to the methylation status of promoter sites of genes that coordinate cell growth, differentiation, and survival [20]. The gene discussed is JAK2; the disease is myeloproliferative neoplasm.