NFKB1 and neoplasm: Importantly, reduced TET2 expression in CRC correlates with diminished cytotoxic T-cell infiltration and altered macrophage polarization, fostering a pro-tumorigenic microenvironment [38], while higher TET2 expression enhances antigen presentation, Th1/Th2/Th17 differentiation, and NF-κB signaling, thereby strengthening anti-tumor immunity [38].