ER stress-mediated non-canonical STING activation also drives various cardiac diseases, such as angiotensin II (Ang II) and aortic constriction (AC)-mediate cardiac inflammation and fibrosis [74], ischemia/reperfusion induced- myocardial injury [77] and hyperlipidemia induced-microvasculitis [78]. This evidence concerns the gene STING1 and hyperlipidemia.