STING1 and autoimmune interstitial lung disease-arthritis syndrome: This clearly indicates that STING can be triggered by a wide spectrum of PRRs-independent mechanisms, including gain-of-function mutations (e.g., SAVI) [68,98,200], ER stress [73,201], trafficking defects (COPA syndrome) [202,203,204], impaired lysosomal degradation (NPC disease) [86,205,206], and various forms of cellular stress and death [207].