Host Dnases, including TREX1, ribonuclease HII complex, SAM and HD domain containing protein 1 (SAMHD1), adenosine deaminase acting on RNA 1 (ADAR1), interferon induced with helicase C domain 1 (IFIH1), U7 small nuclear RNA associated protein (LSM11), and U7 small nuclear 1 (RNU7-1), are responsible for degrading this abnormally accumulated DNA, thereby preventing autoimmunity. Here, TREX1 is linked to Autoimmunity.