Beyond the physiological function of immune homeostasis and immune tolerance, LAIR1 has been involved in several autoimmune and inflammatory conditions and neoplasia [156], including allergy [200], systemic lupus erythematosus [201], rheumatoid arthritis [175,202,203], graft rejection [204], breast carcinoma [205], glioma [206], solid tumors [207], and hepatocellular carcinoma [208], among others. This evidence concerns the gene LAIR1 and central nervous system cancer.