Other studies show that boosting EV delivery of miR-146a ameliorates synaptic dysfunction and promotes synaptogenesis [56], while hippocampal EVs collected after an experimental stroke exhibited reduced synapse-associated proteins (e.g., Synaptotagmin, PSD-95), which is associated with diminished spine density and altered trophic signaling [57]. This evidence concerns the gene DLG4 and stroke disorder.