So, this study demonstrated that the expression of the cyto- and chemokines CCL3 and VEGF are largely dependent on the p53 status of cancer cells, with an increase in CCL3 and VEGF observed in HCT116p53+/+ and HCT116P53+/− cells, but not in HCT116P53−/− cells. This evidence concerns the gene TP53 and cancer.