Mechanistically, MUC16/CA125 promotes immune evasion in multiple malignancies by suppressing natural killer (NK) and T-cell function via tumor-associated regulatory T cells (Tregs) [35], and MUC16/CA125 has been shown to suppress antitumor immune responses by inhibiting the function of natural killer (NK) cells and T cells. Here, MUC16 is linked to neoplasm.