MUC16 and neoplasm: Multivariate Cox regression analysis showed that capsule [hazard ratio (HR) = 0.42; 95% confidence interval (CI), 0.27–0.63; p < 0.001], BCLC [hazard ratio (HR) = 1.85; 95% confidence interval (CI), 1.30–2.63; p < 0.001], CA125 (HR = 1.01; 95% CI, 1.01–1.02; p < 0.001), tumor size (HR = 1.06; 95% CI, 1.00–1.13; p = 0.043) were independent risk factors for postoperative recurrence of MVI-negative HCC patients (Supplementary Figure S1).