To validate biomarker reproducibility, findings were tested on an independent external cohort (GSE114135 SuperSeries dataset, n = 342) containing RNA-Seq and DNA methylation profiles from naïve CD4+ T-cells of infants and children with/without food allergies using the same Illumina HumanMethylation850 BeadChip platform. The gene discussed is CD4; the disease is food allergy.