PGP and hypopharyngeal carcinoma: A similar phenomenon has been observed in hypopharyngeal carcinoma, with a study by Lu et al. [32] demonstrating that the hypopharyngeal carcinoma cell line FaDu, after induction of chemoresistance by paclitaxel, exhibited elevated expression of Twist1 and MDR1/P-gp in an MDR-dependent manner, suggesting that Twist1 contributes to chemoresistance in hypopharyngeal carcinoma cells by upregulating MDR1/P-gp.