During cancer pathogenesis, TP73 may promote genomic instability, pro-proliferative signalling, evasion of growth suppression, activation of invasion and metastasis, angiogenesis, immune evasion, altered cellular energetics, neoneurogenesis, and cytotoxic therapy resistance [10,11,12,13,14,15,16,17]. The gene discussed is TP73; the disease is cancer.