EDN1 and neurodegenerative disease: In the literature, we identified multiple studies revealing neurological conditions associated with elevations of endothelin-1 in plasma and/or cerebro-spinal fluid (CSF), affecting both the central (CNS) and the peripheral nervous system (PNS), including neuroinflammation, stroke, neurodegenerative diseases, traumatic brain injury, Alzheimer’s disease, and post-COVID syndrome [47,48,49,50,51].