EDN1 and coronary atherosclerosis: Given the fact that its primary effect is vasoconstriction, ET-1 can directly or indirectly determine a multitude of cardiovascular changes and is therefore implicated in numerous pathophysiological mechanisms underlying this system and conditions such as coronary atherosclerosis and disease [4,7], arterial hypertension [18], cardiac fibrosis [19] and heart failure [20,21,22].