EDN1 and heart failure: Given the fact that ET receptors determine fibroblast activation and myofibroblast differentiation (resulting in a higher expression of α-smooth muscle actin and collagens, cardiac fibrosis and ultimately to heart failure) when stimulated by ET-1, in a study published by Duangrat et al. [19], the authors sought to analyze this effect, the steps leading to it and whether or not reversing myofibroblast differentiation could represent a potential therapeutic strategy.