Alpha-synuclein (α-synuclein) aggregates constitute PD’s pathological hallmark, as previous studies indicate it has a role in modulating the dopamine (DA) release in the striatal region, by increasing intracellular Ca2+, disrupting neuronal intracellular homeostasis, resulting in a neurotoxicity cascade and neurodegeneration [13,14,15]. Here, SNCA is linked to Parkinson disease.