REN and diabetes mellitus: Notably, the FinnGen-based associations involved medications typically prescribed for cardiovascular or metabolic conditions (e.g., agents acting on the renin–angiotensin system, diuretics, thyroid preparations, and diabetes drugs); in comparison, the UK Biobank-based associations were observed for medications more commonly used for pain or respiratory diseases (e.g., opioids, adrenergics, inhalants, and glucocorticoids).