Although rs2234235 in TAS2R1 was associated with the spike antibody in the entire cohort (OR: 0.74; CI: 0.57, 0.98; p = 0.033), a subgroup analysis revealed a significant association only in patients with respiratory disease (OR: 0.48; CI: 0.27, 0.85; p = 0.012) and with a trend toward significance in patients with IMID (OR: 0.37; CI: 0.13, 1.04; p = 0.058). The gene discussed is TAS2R1; the disease is respiratory system disorder.