STING1 and STING-associated vasculopathy with onset in infancy: Human genetics also offers natural experiments: monogenic interferonopathies such as TREX1-, ADAR1-, or STING1-associated disorders are caused by constitutive IFN-I signaling and result in inflammatory phenotypes, while therapeutic improvement with JAK inhibition in syndromes such as SAVI underscores the pathogenic role of this pathway [174].