Abbreviations: CLE, cutaneous lupus erythematosus; DM, dermatomyositis; IBD, inflammatory bowel disease; MS, multiple sclerosis; pSS, primary Sjögren’s syndrome; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; SSc, systemic sclerosis; SAVI, STING-associated vasculopathy; and T1D, type 1 diabetes. The gene discussed is STING1; the disease is rheumatoid arthritis.