Most samples expressed between one and two EZH2 transcripts (Figure 3B), including the canonical variant and the variant with intron 9 retention; however, one patient with group 4 medulloblastoma expressed four alternative EZH2 transcripts and had no expression of the canonical variant, so we speculate that one of these alternative variants could negatively regulate the canonical transcript, as has been observed with the variant lacking the SET domain in a group 3 medulloblastoma model [19]. This evidence concerns the gene SET and medulloblastoma.