In chronic myeloid leukemia, the EZH2 variant lacking exons 11 and/or 12 is related to decreased protein expression of EZH2; as a possible explanation, Shiozawa et al. reported that the skipping of exon 11 leads to a premature stop codon [63]. Here, EZH2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.