We hypothesize that the binding of PGRMC1 to the VIM-S39 domain may exert an antagonistic effect, promoting tumor cell migration and invasion, as well as the development of cervical intraepithelial neoplasia, by occupying the phosphorylation activation site on VIM and inhibiting phosphorylation at the VIM-S39 site. The gene discussed is PGRMC1; the disease is neoplasm.