GPT and obesity due to melanocortin 4 receptor deficiency: A meta-analysis across ten studies (nine observational and one randomized trial), IGB therapy in patients with obesity led to significant reductions in liver enzymes (ALT decreased by 10.02 U/L [95% CI: −13.2, −6.8]; GGT decreased by 9.82 U/L [95% CI: −12.9, −6.8]) and BMI (−4.98 kg/m2 [95% CI: −5.6, −4.4]) at six months.