These three types of myeloid immune cells play a key role in adipose tissue homeostasis and metabolic regulation, with cDC1 participating in immune activation through antigen presentation [48], cDC2B having pro-inflammatory properties and driving local inflammatory responses [49], and Myeloid-like cells remodeling the microenvironment, possibly through immune-suppressive functions, which collectively form the core of the obesity-associated chronic inflammation cell population. This evidence concerns the gene MPPE1 and obesity due to melanocortin 4 receptor deficiency.