CCT3 and colorectal adenocarcinoma: Moreover, the receiver operating characteristic (ROC) curve analysis demonstrated that the circ-CCT3 expression may very efficiently distinguish colorectal adenocarcinoma from normal colorectal mucosa [area under the ROC curve (AUC) = 0.92, 95% CI = 0.89–0.95, p < 0.001] (Figure 2).