APOB and atherosclerosis: The diminished LDL-apoB production may attenuate the effects of Lp-PLA2 when its activity is insufficient, thereby allowing the anti-atherosclerotic effects of HDL-Lp-PLA2 to overshadow the role of LDL-bound Lp-PLA2 as a risk factor for atherosclerosis at lower Lp-PLA2 activity levels, which may reduce its predictive value in atherosclerosis [27].