Given the potential alteration of electrical impulse conductance in the myocardium and the association between ASD and NKX2-5, TBX5, and PRRX1 gene mutations, this review aims to investigate the clinical prevalence of atrioventricular block, bundle branch block, fascicular block, bradycardia, and the need for pacemakers in patients with ASD. This evidence concerns the gene NKX2-5 and atrial septal defect.