Currently, genetic models [12], toxin-based paradigms using 6-hydroxydopamine [13], rotenone [14,15], paraquat [16], and reserpine [17], as well as central administration of α-synuclein fibrils [18] and viral vectors [19] have been used to induce PD-like symptoms in rats and mice, among other paradigms [10]. Here, SNCA is linked to Parkinson disease.