To determine whether the protective effects of RORB knockdown observed in RhoP23H mice, characterized by retinal degeneration driven by proteotoxic stress, are relevant across different RP models, we also tested cp-asiRORB in rd10 mice, a model in which retinal degeneration is primarily caused by disrupted calcium homeostasis rather than proteostasis imbalance [22,23]. This evidence concerns the gene RORB and retinal degeneration.