IDH2 and low grade glioma: Adult-type diffuse gliomas are the most frequent tumors of the central nervous system (CNS), characterized by an extensive infiltrative growth with an overall survival that greatly varies depending on the specific subtype and histological grade, ranging from 7 to 15 years in Isocitrate Dehydrogenase (IDH)-mutant low-grade gliomas (LGGs) to 12–24 months in grade 4 IDH-wildtype gliomas [1,2].