In IDH-mutant AR-positive grade 3 astrocytomas, the mOS was 137 months (p-value 0.81; HR = 0.71 (95%CI 0.04–11.8)), while in IDH-mutant AR-negative grade 3 astrocytomas, the mOS was 128 months. Here, IDH2 is linked to astrocytoma (excluding glioblastoma).