TRIM72 and aortic valve disorder: Although echocardiography showed no difference in peak aortic valve velocity between 10-month-old Trim72−/− (MG53-deficient) and wild-type (WT) mice, the mean peak velocity in Trim72−/− mice increased significantly from 1274 ± 66.3 cm/s at 10 months to 2929 ± 1073 cm/s at 24 months (Δv vs. WT, p < 0.0001), providing hemodynamic evidence of progressive aortic valve disease [86].