A study demonstrated significantly reduced expression ofiiALOX5, the gene encoding 5-lipoxygenase (5-LO)—an enzyme critical for LXA4 synthesis—in airway macrophages and dendritic cells of patients with severe COVID-19 in comparison with healthy people, indicating that impaired biosynthesis of 5-LO-derived SPMs may be involved in SARS-CoV-2 pathogenesis [32]. The gene discussed is ALOX5; the disease is COVID-19.